Absence of Myofibroblasts in Subsynovial Connective Tissues in Human and Rabbit Models of Carpal Tunnel Syndrome
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چکیده
INTRODUCTION: The most common histological finding of carpal tunnel syndrome (CTS) is non-inflammatory fibrosis of the subsynovial connective tissue (SSCT) in the carpal tunnel. The etiology of this finding and its relationship to the development of CTS remain poorly understood. Myofibroblasts, contractile fibroblasts which express alpha-smooth muscle actin (α-SMA), have a key role in wound healing and many other pathological conditions characterized by fibrosis. The purpose of this study was to determine if myofibroblasts were associated with SSCT fibrosis in CTS patients or in a rabbit model of SSCT fibrosis and CTS.
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Effects of Shear Injury on the Subsynovial Connective Tissue and Median Nerve within the Rabbit Carpal Tunnel: A Potential Animal Model of Carpal Tunnel Syndrome
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Carpal tunnel syndrome (CTS) is a very common pathology. Its most common diagnosis is idiopathic. Although it is accepted that chronic increase in pressure within the carpal tunnel is responsible for median nerve neuropathy, the exact pathophysiology leading to this pressure increase remains unknown. All the histological studies of the carpal tunnel in the CTS find a noninflammatory thickening ...
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